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EnglishThe inclusion of polyphenols into nanoporous materials may significantly improve their application as radical trapping agents for therapeutic purposes. In the present work, nanosponges based on hyper-cross-linked cyclodextrins and calixarenes (NS1-NS3) were used as carriers of three natural phenolic antioxidants: quercetin (Que), curcumin (Cur) and phenethyl caffeate (Phec). Good w/w loadings, namely 7.3% for the Que-NS1 composite, 17.3% for Cur-NS2 and 12.9% for Phec-NS3, were achieved. The release kinetics and the inhibition rate constants (k(inh)) of the reaction with alkylperoxyl radicals (ROO) in 0.1 M phosphate buffer solutions at pH 7.4 were studied and indicated better antioxidant activity as compared to the phenols alone. The three phenols suffered a dramatic reduction of k(inh) upon increasing their concentration, as a result of their degradation. The inclusion into the nanosponges protected the antioxidants and provided a controlled release in an aqueous medium. Hence, different applications can be envisaged, in food and pharmaceutical technology fields.
| Titolo: | Nanosponges for the protection and release of the natural phenolic antioxidants quercetin, curcumin and phenethyl caffeate | |
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| Data di pubblicazione: | 2020 | |
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| Handle: | http://hdl.handle.net/11697/158824 | |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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