We predict disease-genes relations on the human interactome network using a methodology that jointly learns functional and connectivity patterns surrounding proteins. Contrary to other data structures, the Interactome is characterized by high incompleteness and the absence of explicit negative knowledge, which makes predictive tasks particularly challenging. To exploit at best latent information in the network, we propose an extended version of random walks, named Random Watcher-Walker (RW2), which is shown to perform better than other state-of-the-art algorithms. We also show that the performance ofRW2and other compared state-of-the-art algorithms is extremely sensitive to the interactome used, and to the adopted disease categorizations, since this influences the ability to capture regularities in presence of sparsity and incompleteness

A feature-learning-based method for the disease-gene prediction problem

Giovanni Stilo
Membro del Collaboration Group
;
2020

Abstract

We predict disease-genes relations on the human interactome network using a methodology that jointly learns functional and connectivity patterns surrounding proteins. Contrary to other data structures, the Interactome is characterized by high incompleteness and the absence of explicit negative knowledge, which makes predictive tasks particularly challenging. To exploit at best latent information in the network, we propose an extended version of random walks, named Random Watcher-Walker (RW2), which is shown to perform better than other state-of-the-art algorithms. We also show that the performance ofRW2and other compared state-of-the-art algorithms is extremely sensitive to the interactome used, and to the adopted disease categorizations, since this influences the ability to capture regularities in presence of sparsity and incompleteness
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/160320
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