Autoinflammatory diseases are a group of clinical conditions other than autoimmune diseases, characterized by recurrent inflammatory episodes. From a pathogenetic point of view they are determined by a dysregulation of innate immunity, without involvement of specific immunity (autoreactive T cells and autoantibodies). Recently, the increased knowledge in the field of autoinflammation highlighted shared immune mechanisms in the pathogenesis of both classical monogenetic and multifactorial autoinflammatory diseases and a broad spectrum of chronic age-related inflammatory pathologies. The current increase in the prevalence of chronic inflammatory diseases makes this subject of topical interest. In the light of these considerations, we propose an update of autoinflammatory diseases and a new interpretation of autoinflammation with both theoretical and clinical implications.
An update on autoinflammatory diseases
DE MARTINIS, MASSIMO MARIA MARCELLO;GINALDI, Lia
2014-01-01
Abstract
Autoinflammatory diseases are a group of clinical conditions other than autoimmune diseases, characterized by recurrent inflammatory episodes. From a pathogenetic point of view they are determined by a dysregulation of innate immunity, without involvement of specific immunity (autoreactive T cells and autoantibodies). Recently, the increased knowledge in the field of autoinflammation highlighted shared immune mechanisms in the pathogenesis of both classical monogenetic and multifactorial autoinflammatory diseases and a broad spectrum of chronic age-related inflammatory pathologies. The current increase in the prevalence of chronic inflammatory diseases makes this subject of topical interest. In the light of these considerations, we propose an update of autoinflammatory diseases and a new interpretation of autoinflammation with both theoretical and clinical implications.Pubblicazioni consigliate
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