The cyclization of 2-alkynylanilines in the presence of PdCl2 and nBu4NCl under an acidic CH2Cl2-HCI two-phase system affords 2-substituted indoles in good to high yield, at room temperature. The reaction is particularly suited to the one-flask preparation of 2-substituted indoles from 2-ethynylaniline.
Titolo: | PALLADIUM-CATALYZED CYCLIZATION OF 2-ALKYNYLANILINES TO 2-SUBSTITUTED INDOLES UNDER AN ACIDIC 2-PHASE SYSTEM |
Autori: | |
Data di pubblicazione: | 1994 |
Rivista: | |
Abstract: | The cyclization of 2-alkynylanilines in the presence of PdCl2 and nBu4NCl under an acidic CH2Cl2-HCI two-phase system affords 2-substituted indoles in good to high yield, at room temperature. The reaction is particularly suited to the one-flask preparation of 2-substituted indoles from 2-ethynylaniline. |
Handle: | http://hdl.handle.net/11697/16849 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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