The cyclization of 2-alkynylanilines in the presence of PdCl2 and nBu4NCl under an acidic CH2Cl2-HCI two-phase system affords 2-substituted indoles in good to high yield, at room temperature. The reaction is particularly suited to the one-flask preparation of 2-substituted indoles from 2-ethynylaniline.

PALLADIUM-CATALYZED CYCLIZATION OF 2-ALKYNYLANILINES TO 2-SUBSTITUTED INDOLES UNDER AN ACIDIC 2-PHASE SYSTEM

MARINELLI, Fabio
1994

Abstract

The cyclization of 2-alkynylanilines in the presence of PdCl2 and nBu4NCl under an acidic CH2Cl2-HCI two-phase system affords 2-substituted indoles in good to high yield, at room temperature. The reaction is particularly suited to the one-flask preparation of 2-substituted indoles from 2-ethynylaniline.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/16849
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