Oxazolidine-2,4-diones were synthesised by tetraethylammonium hydrogen carbonate (TEAHC) promoted carboxylation of secondary carboxamides bearing a leaving group at the alpha-position. Several oxazolidine-2,4-diones, including clinically used malidone(R), have been prepared in moderate to excellent yields as a results of a formal proton extraction-carboxylation-intramolecular SN2 one-pot sequence.
Tetraethylammonium Hydrogen Carbonate in Organic Synthesis: Synthesis of Oxazolidine-2,4-diones
MUCCIANTE, VITTORIA;ROSSI, LEUCIO
1999-01-01
Abstract
Oxazolidine-2,4-diones were synthesised by tetraethylammonium hydrogen carbonate (TEAHC) promoted carboxylation of secondary carboxamides bearing a leaving group at the alpha-position. Several oxazolidine-2,4-diones, including clinically used malidone(R), have been prepared in moderate to excellent yields as a results of a formal proton extraction-carboxylation-intramolecular SN2 one-pot sequence.File in questo prodotto:
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