Apoptosis represents a fundamental process during fetal/post-natal testis development. Therefore pro- and antiapoptotic proteins are essential to regulate testis physiology. c-FlipL is a known inhibitor of caspase 8/10 activity; in this study its perinatal expression in mouse male germ cells was investigated. In testis sections and seminiferous tubule whole mount c-FlipL was found to be expressed in undifferentiated spermatogonia and to co-localize with germ stem cells markers. In vivo investigations in the vitamin-A deficient mouse, lacking differentiated germ cells, confirmed c-FlipL expression in undifferentiated spermatogonia. Further analyses showed Fas expression but no significant caspase 8/10 activity when c-FlipL was highly expressed. Altogether these data suggest that c-Flip may control the survival rate of undifferentiated spermatogonia

c-Flip(L) is expressed in undifferentiated mouse male germ cells.

DE CESARIS, Paola;
2006-01-01

Abstract

Apoptosis represents a fundamental process during fetal/post-natal testis development. Therefore pro- and antiapoptotic proteins are essential to regulate testis physiology. c-FlipL is a known inhibitor of caspase 8/10 activity; in this study its perinatal expression in mouse male germ cells was investigated. In testis sections and seminiferous tubule whole mount c-FlipL was found to be expressed in undifferentiated spermatogonia and to co-localize with germ stem cells markers. In vivo investigations in the vitamin-A deficient mouse, lacking differentiated germ cells, confirmed c-FlipL expression in undifferentiated spermatogonia. Further analyses showed Fas expression but no significant caspase 8/10 activity when c-FlipL was highly expressed. Altogether these data suggest that c-Flip may control the survival rate of undifferentiated spermatogonia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/18468
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