An analytical solution for solving the transient drug diffusion in adjoining porous wall layers faced with a drug-eluting stent is presented. The endothelium, intima, internal elastic lamina and media are all treated as homogeneous porous media and the drug transfer through them is modelled by a set of coupled partial differential equations. The classical separation of variables method for a multi-layer configuration is used. The model addresses the concept of penetration depth for multi-layer solids that is useful to treat the wall thickness by estimating a physical bound for mass diffusion. Drug concentration level and mass profiles in each layer at various times are given and discussed.
A multi-layer wall porous model for coronary drug-eluting stents
DE MONTE, FILIPPO
2010-01-01
Abstract
An analytical solution for solving the transient drug diffusion in adjoining porous wall layers faced with a drug-eluting stent is presented. The endothelium, intima, internal elastic lamina and media are all treated as homogeneous porous media and the drug transfer through them is modelled by a set of coupled partial differential equations. The classical separation of variables method for a multi-layer configuration is used. The model addresses the concept of penetration depth for multi-layer solids that is useful to treat the wall thickness by estimating a physical bound for mass diffusion. Drug concentration level and mass profiles in each layer at various times are given and discussed.Pubblicazioni consigliate
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