Mutations of the isocitrate dehydrogenase (IDH) gene occur in over 80% of low-grade gliomas and secondary glioblastomas. Despite considerable efforts, endogenous in vitro IDH-mutated glioma models remain scarce. Availability of these models is key for the development of new therapeutic interventions.

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures

Mastroberardino, Pier G;
2021-01-01

Abstract

Mutations of the isocitrate dehydrogenase (IDH) gene occur in over 80% of low-grade gliomas and secondary glioblastomas. Despite considerable efforts, endogenous in vitro IDH-mutated glioma models remain scarce. Availability of these models is key for the development of new therapeutic interventions.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/195410
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