N-Boc derivatives of Met, Cys, and Trp, the properties of which resemble those of the respective amino acid residues present in proteins, are efficiently oxidized by methyltrioxorhenium and H2O2. A high regioselectivity for the oxidation of these residues when embedded into peptides was also found.
A novel oxidative side-chain transformation of alfa-amino acids and peptides by methyltrioxorhenium/H2O2 system
CRUCIANELLI, MARCELLO;DE ANGELIS, Francesco;
2004-01-01
Abstract
N-Boc derivatives of Met, Cys, and Trp, the properties of which resemble those of the respective amino acid residues present in proteins, are efficiently oxidized by methyltrioxorhenium and H2O2. A high regioselectivity for the oxidation of these residues when embedded into peptides was also found.File in questo prodotto:
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