Experimental results and computational insights explain the key role of transition-metal catalysis/Brønsted acid synergism in the achievement of the sequential regioselective direct heteroarylation/ cyclocondensation reactions of β-(2-aminophenyl)-α,β-ynones with a variety of electron-rich aromatic heterocyclic/arenes to afford quinoline- (hetero)aromatic hybrids. The first approach to the synthesis of 4-(1Hpyrrol- 2-yl)quinolines is described. The effectiveness of various transition metals is compared.
Direct Regioselective Hydro(hetero)arylation/Cyclocondensation Reactions of β‑(2-Aminophenyl)-α,β-ynones by Means of Transition-Metal Catalysis/Brønsted Acid Synergism: Experimental Results and Computational Insights
Vincenzo MarsicanoMembro del Collaboration Group
;Antonio Arcadi
Membro del Collaboration Group
;Massimiliano Aschi
Membro del Collaboration Group
;Marco ChiariniMembro del Collaboration Group
;Fabio MarinelliMembro del Collaboration Group
;
2023-01-01
Abstract
Experimental results and computational insights explain the key role of transition-metal catalysis/Brønsted acid synergism in the achievement of the sequential regioselective direct heteroarylation/ cyclocondensation reactions of β-(2-aminophenyl)-α,β-ynones with a variety of electron-rich aromatic heterocyclic/arenes to afford quinoline- (hetero)aromatic hybrids. The first approach to the synthesis of 4-(1Hpyrrol- 2-yl)quinolines is described. The effectiveness of various transition metals is compared.File in questo prodotto:
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