Background: Perivascular epithelioid cell tumors (PEComa)s are mesenchymal neoplasms located at various anatomic sites, which usually express both melanocytic and myogenic markers.Case Report: A 60-year-old woman underwent laparotomy for a huge, heterogeneous, right ovarian mass.The histological examination of the surgical specimen revealed a neoplasm consisting of both cells with clear or eosinophilic cytoplasm and spindle cells in a myxoid stroma.Immunostaining was positive for human melanoma black-45, h-caldesmon, desmin, actin, and transcription factor 3.Cell atypias were moderate, mitoses were 4/10 high power fields (HPF) and margins were focally infiltrative.These findings pointed to a diagnosis of ovarian PEComa.Twenty-five months later, two subcutaneous lesions were surgically removed on the left trapezius muscle and the median subumbilical area, respectively.The former was a desmoid fibromatosis, whereas the latter was a recurrence of PEComa with greater nuclear pleomorphism and higher number of mitoses (26/50 HPF) compared to the primary tumor.The patient was free of disease 11 months later.Conclusion: A long-term follow-up of gynecological PEComas is strongly recommended.

Primary perivascular epithelioid cell tumor (pecoma) of the ovary: A case report and review of the literature

Vistoli F.;
2021-01-01

Abstract

Background: Perivascular epithelioid cell tumors (PEComa)s are mesenchymal neoplasms located at various anatomic sites, which usually express both melanocytic and myogenic markers.Case Report: A 60-year-old woman underwent laparotomy for a huge, heterogeneous, right ovarian mass.The histological examination of the surgical specimen revealed a neoplasm consisting of both cells with clear or eosinophilic cytoplasm and spindle cells in a myxoid stroma.Immunostaining was positive for human melanoma black-45, h-caldesmon, desmin, actin, and transcription factor 3.Cell atypias were moderate, mitoses were 4/10 high power fields (HPF) and margins were focally infiltrative.These findings pointed to a diagnosis of ovarian PEComa.Twenty-five months later, two subcutaneous lesions were surgically removed on the left trapezius muscle and the median subumbilical area, respectively.The former was a desmoid fibromatosis, whereas the latter was a recurrence of PEComa with greater nuclear pleomorphism and higher number of mitoses (26/50 HPF) compared to the primary tumor.The patient was free of disease 11 months later.Conclusion: A long-term follow-up of gynecological PEComas is strongly recommended.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/221676
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