The study ascertained the protective effect of orally administered doxofylline toward bronchospasm induced by metacholine in a double-blind cross-over trial, versus theophylline slow-release, in patients with chronic bronchitis. The results demonstrated a statistically significant increase of PD20 exerted by both xanthine derivatives. No changes in FEV1 occurred with either drug. In conclusion, doxofylline showed to be equally effective as theophylline in protecting patients from bronchial spasm yielded by methacholine
Variations in aspecific bronchial reactivity elicited by methacholine in chronic bronchitis patients treated with doxofylline. Double blind cross-over study versus theophylline slow-release
Mutti L.;
1991-01-01
Abstract
The study ascertained the protective effect of orally administered doxofylline toward bronchospasm induced by metacholine in a double-blind cross-over trial, versus theophylline slow-release, in patients with chronic bronchitis. The results demonstrated a statistically significant increase of PD20 exerted by both xanthine derivatives. No changes in FEV1 occurred with either drug. In conclusion, doxofylline showed to be equally effective as theophylline in protecting patients from bronchial spasm yielded by methacholineFile in questo prodotto:
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