A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (−)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials. A Piers–Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-OH CBD from commercially available CBD, in 31% overall yield.

Piers–Rubinsztajn reaction to unlock an 8-step synthesis of 7-hydroxy cannabidiol

Cocco, Emanuele;Iapadre, Debora;Brusa, Alessandro;Pesciaioli, Fabio
;
Carlone, Armando
2024-01-01

Abstract

A scalable synthesis of 7-hydroxy cannabidiol (7-OH CBD), a primary metabolite of (−)-cannabidiol (CBD), is highly desirable, from an industrial point of view, to enable future clinical trials. A Piers–Rubinsztajn reaction was key to enable a mild deprotection and a concise synthesis of 7-OH CBD from commercially available CBD, in 31% overall yield.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/224399
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