2-Ethynyl-3-pyridinols and 3-ethynyl-2-pyridinols, readily available from halopyridinols, have been treated with aryl/ heteroaryl halides or vinyl triflates to give 2-substituted furo[3,2-b]pyridines and 2-substituted furo[2,3-b]pyridines through a coupling/cyclization process. Two catalyst systems have been used: PdCl2(PPh3)(2)-CuI and Pd-2(dba)(3)-P(t-Bu)(3). Halopyridinols have been employed for an alternative approach to 2-substituted furo[2,3-b]pyridines and 2-substituted furo[2,3-c]pyridines via 2(trimethylsilyl)furopyridines,

New efficient approaches to functionalisezed 2-substituted furopyridines

A. ARCADI;MARINELLI, Fabio
2002-01-01

Abstract

2-Ethynyl-3-pyridinols and 3-ethynyl-2-pyridinols, readily available from halopyridinols, have been treated with aryl/ heteroaryl halides or vinyl triflates to give 2-substituted furo[3,2-b]pyridines and 2-substituted furo[2,3-b]pyridines through a coupling/cyclization process. Two catalyst systems have been used: PdCl2(PPh3)(2)-CuI and Pd-2(dba)(3)-P(t-Bu)(3). Halopyridinols have been employed for an alternative approach to 2-substituted furo[2,3-b]pyridines and 2-substituted furo[2,3-c]pyridines via 2(trimethylsilyl)furopyridines,
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/23099
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