The Pt-cathode hydrogen evolution reaction (Pt-HER) of acetone cyanohydrin provides an alternative method for introducing the cyano group onto electrophilic carbons of imines and chalcones. The synthesis of α-aminonitriles and β-cyano ketones has been achieved smoothly with a small excess of cyanating agent (2 equivalent), catalytic amount of supporting electrolyte and low electricity consumption (0.02 F/mol). Besides demonstrating a general atom economy, the high Faradaic efficiency, allows for a scale-up with low-demanding electrochemical design and short electrolysis times.
Electrocatalytic Hydrogen Evolution Reaction Enabling Cyanation of Electron-poor Carbons with Acetone Cyanohydrin
Morlacci V.;Momoli C.;Aschi M.;Arcadi A.;Palombi L.
2024-01-01
Abstract
The Pt-cathode hydrogen evolution reaction (Pt-HER) of acetone cyanohydrin provides an alternative method for introducing the cyano group onto electrophilic carbons of imines and chalcones. The synthesis of α-aminonitriles and β-cyano ketones has been achieved smoothly with a small excess of cyanating agent (2 equivalent), catalytic amount of supporting electrolyte and low electricity consumption (0.02 F/mol). Besides demonstrating a general atom economy, the high Faradaic efficiency, allows for a scale-up with low-demanding electrochemical design and short electrolysis times.File in questo prodotto:
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