The cell ultrastructure and some detoxifying enzyme activities were studied in skeletal muscles of young rats kept for 84 h under normobaric hyperoxia (95% O2) or normoxia as control. Rat were injected ip. Every 12 h either with lml saline, 1 ml saline +30 mg hypotaurine or 1 ml saline +30 mg taurine. Ultrastructural observation revealed an highly protective effect on tissue damages due to hyperoxia in taurinetreated rats and, at less extent, in hypotaurine-treated ones. Enzymatic assays suggest a different mechanism of the two molecules in their protective action.

Biochemical and ultrastructural alterations in rat after hyperoxic treatment: effect of taurine and hypotaurine

PITARI, Giuseppina;
2002

Abstract

The cell ultrastructure and some detoxifying enzyme activities were studied in skeletal muscles of young rats kept for 84 h under normobaric hyperoxia (95% O2) or normoxia as control. Rat were injected ip. Every 12 h either with lml saline, 1 ml saline +30 mg hypotaurine or 1 ml saline +30 mg taurine. Ultrastructural observation revealed an highly protective effect on tissue damages due to hyperoxia in taurinetreated rats and, at less extent, in hypotaurine-treated ones. Enzymatic assays suggest a different mechanism of the two molecules in their protective action.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/2405
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