Histomorphometric comparison between Bio-oss and Sintlife dental in postextraction bone regeneration: a clinical experimental study

This clinical experimental study aims to compare the histomorphometric outcomes of two biomaterials—Bio-Oss, a bovine bone substitute, and Sintlife Dental, a magnesium-enriched hydroxyapatite—in post-extraction alveolar ridge regeneration. Twenty patients requiring tooth extraction were randomly assigned to either the Test group (Sintlife Dental) or the Control group (Bio-Oss). Biopsies were collected approximately six months after surgery using quantitative histology to evaluate new bone formation, residual graft material, and intertrabecular spaces. Results indicated that both biomaterials supported bone regeneration; however, Bio-Oss showed a higher percentage of newly formed bone and more residual material, aligning with its reputation as the gold standard in bone grafting. Sintlife Dental exhibited a greater tendency toward resorption and fibrous tissue formation. Patient-specific factors such as anatomical conditions and residual bone volume influenced regenerative outcomes. These findings support the effective use of both materials in clinical practice, with Bio-Oss demonstrating superior performance in this sample. Ongoing research with larger cohorts aims to deepen the understanding of biomaterial-bone interactions.