Existing retrosynthesis AI often inherits literature popularity bias. We introduce Synthonpedia, an open-access, community-driven platform redefining synthetic planning through human-machine cooperation. Using connectivity-based "radical synthons", it streamlines graph matching with minimal computational footprint. A proof-of-concept on clavulanic acid reveals non-intuitive, unbiased disconnections on consumer-grade hardware.
Synthonpedia: A Sustainable and Unbiased Paradigm for the Democratization of Retrosynthetic Knowledge
Brusa, Alessandro
;Carlone, Armando
2026-01-01
Abstract
Existing retrosynthesis AI often inherits literature popularity bias. We introduce Synthonpedia, an open-access, community-driven platform redefining synthetic planning through human-machine cooperation. Using connectivity-based "radical synthons", it streamlines graph matching with minimal computational footprint. A proof-of-concept on clavulanic acid reveals non-intuitive, unbiased disconnections on consumer-grade hardware.File in questo prodotto:
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