The reaction of the readily available o-ethynyltrifluoroacetanilide with aryl iodides in the presence of catalytic amounts of Pd2dba3, an excess of K2CO3, in DMSO at 40°C affords 2-unsubstituted-3-arylindoles in good yield. Subjection of o-ethynyltrifluoroacetanilide to the same reaction conditions in the absence of aryl iodides gives rise to the formation of indole in high yield.
3-Aryl-2-unsubstituted indoles through the palladium-catalysed reaction of o-ethynyltrifluoroacetanilide with aryl iodides
MARINELLI, Fabio;
1997-01-01
Abstract
The reaction of the readily available o-ethynyltrifluoroacetanilide with aryl iodides in the presence of catalytic amounts of Pd2dba3, an excess of K2CO3, in DMSO at 40°C affords 2-unsubstituted-3-arylindoles in good yield. Subjection of o-ethynyltrifluoroacetanilide to the same reaction conditions in the absence of aryl iodides gives rise to the formation of indole in high yield.File in questo prodotto:
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