NO is a key molecule in the pathogenesis of migraine and other vascular headaches. These data were underlined because of particular interest as they concern migraine in children. It is difficult to prove the correlation between NO in the plasma and platelet activity from this study. Differing values of plasma NO were observed in migrainous children with respect TH and controls. Even if there is not an increased NOS activity in lymphocytes and macrophages, an increased endogenous synthesis of NO in platelet cannot be completely rejected. In fact cytosolic calcium of platelet is greater in controls than the migraineurs. This parameter is a sensitive index in revealing platelet function. The differing values of platelet calcium in migrainous children support the hypothesis of platelet hypofunction.
Nitric Oxide and Platelet Aggregation in Migraineurs Children
TOZZI, Elisabetta;CIFONE, MARIA GRAZIA;
1998-01-01
Abstract
NO is a key molecule in the pathogenesis of migraine and other vascular headaches. These data were underlined because of particular interest as they concern migraine in children. It is difficult to prove the correlation between NO in the plasma and platelet activity from this study. Differing values of plasma NO were observed in migrainous children with respect TH and controls. Even if there is not an increased NOS activity in lymphocytes and macrophages, an increased endogenous synthesis of NO in platelet cannot be completely rejected. In fact cytosolic calcium of platelet is greater in controls than the migraineurs. This parameter is a sensitive index in revealing platelet function. The differing values of platelet calcium in migrainous children support the hypothesis of platelet hypofunction.Pubblicazioni consigliate
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