CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishWe reported recently the Structure-Activity Relationship (SAR) of a class of CXCL8 allosteric modulators. They invariably share a 2-arylpropionic moiety so far considered a key structural determinant of the biological activity. We show the results of recent SAR studies on a novel series of phenylacetic derivatives supported by a combined approach of mutagenesis experiments and conformational analysis. The results suggest novel insights on the. ne role of the propionic/acetic chain in the modulation of CXCL8 receptors. (C) 2009 Elsevier Ltd. All rights reserved.
| Titolo: | Structure–Activity Relationship of novel phenylacetic CXCR1 inhibitors |
| Autori: | |
| Data di pubblicazione: | 2009 |
| Rivista: | |
| Abstract: | We reported recently the Structure-Activity Relationship (SAR) of a class of CXCL8 allosteric modulators. They invariably share a 2-arylpropionic moiety so far considered a key structural determinant of the biological activity. We show the results of recent SAR studies on a novel series of phenylacetic derivatives supported by a combined approach of mutagenesis experiments and conformational analysis. The results suggest novel insights on the. ne role of the propionic/acetic chain in the modulation of CXCL8 receptors. (C) 2009 Elsevier Ltd. All rights reserved. |
| Handle: | http://hdl.handle.net/11697/3632 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
http://hdl.handle.net/11697/3632
Copyright © 2021