Treatment of ethyl 4-aryl/heteroaryl-4-hydroxy-2-butynoates with (S)-alanine and other (S)-amino acid benzyl esters (11 examples) in ethanol or dimethylformamide in the presence of triethylamine provides a general, regioselective entry into N-(3-aryl/heteroaryl-1-ethoxycarbonyl-3-oxopropyl) (S)-amino acid esters, useful intermediates for the synthesis of angiotensin converting enzyme inhibitors
A SIMPLE APPROACH TO N-(3-ARYL-1-ETHOXYCARBONYL-3-OXOPROPYL) (S)-AMINO ACID-ESTERS AND N-(3-HETEROARYL-1-ETHOXYCARBONYL-3-OXOPROPYL) (S)-AMINO ACID-ESTERS
ARCADI, Antonio;MARINELLI, Fabio;
1991-01-01
Abstract
Treatment of ethyl 4-aryl/heteroaryl-4-hydroxy-2-butynoates with (S)-alanine and other (S)-amino acid benzyl esters (11 examples) in ethanol or dimethylformamide in the presence of triethylamine provides a general, regioselective entry into N-(3-aryl/heteroaryl-1-ethoxycarbonyl-3-oxopropyl) (S)-amino acid esters, useful intermediates for the synthesis of angiotensin converting enzyme inhibitorsFile in questo prodotto:
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