Indolylcarboxylate esters 2 and 2-substituted-3-benzylindoles 4 are prepared usually in good yield through the palladium-catalyzed reaction of o-alkynyltrifluoro acetanilides with ethyl iodoacetate or benzyl bromide. Best results are obtained by employing Pd-2(dba)(3) and tris(2,4,6-trimethoxyphenyl)phosphine in THF.
Titolo: | The palladium-catalyzed reaction of o- allkynyltrifluoroacetanilides with alkyl halides. An entry into 2-substituted 3-alkylindoles |
Autori: | |
Data di pubblicazione: | 2000 |
Rivista: | |
Abstract: | Indolylcarboxylate esters 2 and 2-substituted-3-benzylindoles 4 are prepared usually in good yield through the palladium-catalyzed reaction of o-alkynyltrifluoro acetanilides with ethyl iodoacetate or benzyl bromide. Best results are obtained by employing Pd-2(dba)(3) and tris(2,4,6-trimethoxyphenyl)phosphine in THF. |
Handle: | http://hdl.handle.net/11697/4319 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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