Indolylcarboxylate esters 2 and 2-substituted-3-benzylindoles 4 are prepared usually in good yield through the palladium-catalyzed reaction of o-alkynyltrifluoro acetanilides with ethyl iodoacetate or benzyl bromide. Best results are obtained by employing Pd-2(dba)(3) and tris(2,4,6-trimethoxyphenyl)phosphine in THF.
The palladium-catalyzed reaction of o- allkynyltrifluoroacetanilides with alkyl halides. An entry into 2-substituted 3-alkylindoles
A. ARCADI;MARINELLI, Fabio
2000-01-01
Abstract
Indolylcarboxylate esters 2 and 2-substituted-3-benzylindoles 4 are prepared usually in good yield through the palladium-catalyzed reaction of o-alkynyltrifluoro acetanilides with ethyl iodoacetate or benzyl bromide. Best results are obtained by employing Pd-2(dba)(3) and tris(2,4,6-trimethoxyphenyl)phosphine in THF.File in questo prodotto:
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