The brain morphology of cerebral measures from magnetic resonance scans of 50 schizophrenic patients and 40 healthy controls was examined using cluster analysis in order to investigate heterogeneity in schizophrenia. This multivariate analysis defined a cluster of schizophrenics only (28% of patient group) with enlarged ventricular sizes, corpus callosum dimensions at the lower limits of the range of controls, and more severe illness. The remaining two clusters produced were composed of mixed subgroups of patients and controls, schizophrenics showing a milder form of illness. The implications of morphological abnormalities and association with negative/positive symptomatology and sporadic/familial dicotomy in these clusters are discussed.
Brain imaging as a tool to investigate heterogeneity of schizophrenia: A magnetic resonance study
Rossi, A.;SPLENDIANI, ALESSANDRA;Casacchia, M.
1990-01-01
Abstract
The brain morphology of cerebral measures from magnetic resonance scans of 50 schizophrenic patients and 40 healthy controls was examined using cluster analysis in order to investigate heterogeneity in schizophrenia. This multivariate analysis defined a cluster of schizophrenics only (28% of patient group) with enlarged ventricular sizes, corpus callosum dimensions at the lower limits of the range of controls, and more severe illness. The remaining two clusters produced were composed of mixed subgroups of patients and controls, schizophrenics showing a milder form of illness. The implications of morphological abnormalities and association with negative/positive symptomatology and sporadic/familial dicotomy in these clusters are discussed.Pubblicazioni consigliate
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