EFFECTS OF PALLADIUM NANOPARTICLES ON THE CYTOCHINE RELEASE FROM PERIPHERAL BLOOD MONONUCLEAR CELLS IN NON ATOPIC WOMEN

Boscolo, P; Bellante, V; Leopold, K; Maier, M; DI GIAMPAOLO, L; Antonucci, A; Iavicoli, I; Tobia, Loreta; Paoletti, A; Montalti, M; Petrarca, C; Qiaoi, N; Sabbioni, E; DI GIOACCHINO, M.

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The object of this study is to determine the cytokine release from PBMCs exposed to Pd model nanoparticles emitted from catalytic converters. PBMCs of 8 healthy non-atopic women were incubated in the presence of Pd nanoparticles (5-10 nm) or salt (potassium hexa-chloropalladate) 10-5 and 10-6 M. Release of cytokines in supernatant of PBMCs was then determined. In cultures without LPS, IL-10 and IL-17 release from PBMCs was inhibited by Pd salt, while Pd nanoparticles inhibited TNF-α and IL-17 release. In LPSstimulated cultures, release of IFN-gamma, TNF-alpha, IL-10 and IL-17 was inhibited by Pd salt, whereas IFN-gamma release was enhanced and TNF-alpha and IL-17 release was inhibited by Pd nanoparticles. In conclusion, Pd salt inhibits cytokine release, whereas Pd nanoparticles exert modulatory effects enhancing the release of IFN-gamma, a Th1 cytokine typical of delayed allergic reactions. This result is interesting considering the increase of allergic contact dermatitis to Pd in people exposed to Pd nanoparticles in urban environments.

Titolo:	EFFECTS OF PALLADIUM NANOPARTICLES ON THE CYTOCHINE RELEASE FROM PERIPHERAL BLOOD MONONUCLEAR CELLS IN NON ATOPIC WOMEN
Autori:	BOSCOLO P BELLANTE V LEOPOLD K MAIER M DI GIAMPAOLO L ANTONUCCI A IAVICOLI I TOBIA, LORETA PAOLETTI A MONTALTI M PETRARCA C QIAOI N SABBIONI E DI GIOACCHINO M. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2010
Rivista:	JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS
Abstract:	The object of this study is to determine the cytokine release from PBMCs exposed to Pd model nanoparticles emitted from catalytic converters. PBMCs of 8 healthy non-atopic women were incubated in the presence of Pd nanoparticles (5-10 nm) or salt (potassium hexa-chloropalladate) 10-5 and 10-6 M. Release of cytokines in supernatant of PBMCs was then determined. In cultures without LPS, IL-10 and IL-17 release from PBMCs was inhibited by Pd salt, while Pd nanoparticles inhibited TNF-α and IL-17 release. In LPSstimulated cultures, release of IFN-gamma, TNF-alpha, IL-10 and IL-17 was inhibited by Pd salt, whereas IFN-gamma release was enhanced and TNF-alpha and IL-17 release was inhibited by Pd nanoparticles. In conclusion, Pd salt inhibits cytokine release, whereas Pd nanoparticles exert modulatory effects enhancing the release of IFN-gamma, a Th1 cytokine typical of delayed allergic reactions. This result is interesting considering the increase of allergic contact dermatitis to Pd in people exposed to Pd nanoparticles in urban environments.
Handle:	http://hdl.handle.net/11697/6440
Appare nelle tipologie:	1.1 Articolo in rivista

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