Aryl iodides have been found to react with alpha,beta-unsaturated ketones in the presence of catalytic amounts of palladium, an excess of formic acid, and triethylamine, giving rise to conjugate addition type products. The electron-withdrawing power of the group attached to the olefinic double bond, the beta substituent to the carbonyl group, and the basic reaction medium appear to affect greatly the conjugate addition/vinylic substitution ratio.
Palladium-Catalyzed Conjugate Addition Type Reaction of Aryl Iodides with alpha,beta-Unsaturated Ketones
ARCADI, Antonio;
1983-01-01
Abstract
Aryl iodides have been found to react with alpha,beta-unsaturated ketones in the presence of catalytic amounts of palladium, an excess of formic acid, and triethylamine, giving rise to conjugate addition type products. The electron-withdrawing power of the group attached to the olefinic double bond, the beta substituent to the carbonyl group, and the basic reaction medium appear to affect greatly the conjugate addition/vinylic substitution ratio.File in questo prodotto:
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