2,5-Disubstituted oxazoles have been prepared through the reaction of N-propargylamides with aryl iodides in the presence of Pd-2(dba)(3), tri(2-furyl)phosphine, and (NaOBu)-Bu-f. The reaction appears to proceed through a palladium-catalyzed coupling step followed by the in situ cyclization of the resultant coupling product.

Preparation of 2,5-disubstituted oxazoles from N-propargilamides

ARCADI, Antonio;
2001-01-01

Abstract

2,5-Disubstituted oxazoles have been prepared through the reaction of N-propargylamides with aryl iodides in the presence of Pd-2(dba)(3), tri(2-furyl)phosphine, and (NaOBu)-Bu-f. The reaction appears to proceed through a palladium-catalyzed coupling step followed by the in situ cyclization of the resultant coupling product.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/7350
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