The reaction of o-ethynylani lines with o-halotrifluoroacetanilides in the presence of PdCl2,,(PPh3)(2) and Et3N in DMF at 90 degreesC affords 2-(o-trifluoroacetamidoaryl)indoles. The presence of the free amino group was found to play a crucial role in favoring the cyclization step.
Titolo: | 2-(o-Aminoaryl)indole Derivatives via the coupling-Cyclization of o-Alkynylanilines with o-Halotrifluoroacetanilides in the presence of a Palladium Catalyst |
Autori: | |
Data di pubblicazione: | 2004 |
Rivista: | |
Abstract: | The reaction of o-ethynylani lines with o-halotrifluoroacetanilides in the presence of PdCl2,,(PPh3)(2) and Et3N in DMF at 90 degreesC affords 2-(o-trifluoroacetamidoaryl)indoles. The presence of the free amino group was found to play a crucial role in favoring the cyclization step. |
Handle: | http://hdl.handle.net/11697/7707 |
Appare nelle tipologie: | 1.1 Articolo in rivista |
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