The reaction of o-ethynylani lines with o-halotrifluoroacetanilides in the presence of PdCl2,,(PPh3)(2) and Et3N in DMF at 90 degreesC affords 2-(o-trifluoroacetamidoaryl)indoles. The presence of the free amino group was found to play a crucial role in favoring the cyclization step.

2-(o-Aminoaryl)indole Derivatives via the coupling-Cyclization of o-Alkynylanilines with o-Halotrifluoroacetanilides in the presence of a Palladium Catalyst

ARCADI, Antonio;MARINELLI, Fabio
2004

Abstract

The reaction of o-ethynylani lines with o-halotrifluoroacetanilides in the presence of PdCl2,,(PPh3)(2) and Et3N in DMF at 90 degreesC affords 2-(o-trifluoroacetamidoaryl)indoles. The presence of the free amino group was found to play a crucial role in favoring the cyclization step.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/7707
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