The reaction of o-ethynylani lines with o-halotrifluoroacetanilides in the presence of PdCl2,,(PPh3)(2) and Et3N in DMF at 90 degreesC affords 2-(o-trifluoroacetamidoaryl)indoles. The presence of the free amino group was found to play a crucial role in favoring the cyclization step.
2-(o-Aminoaryl)indole Derivatives via the coupling-Cyclization of o-Alkynylanilines with o-Halotrifluoroacetanilides in the presence of a Palladium Catalyst
ARCADI, Antonio;MARINELLI, Fabio
2004-01-01
Abstract
The reaction of o-ethynylani lines with o-halotrifluoroacetanilides in the presence of PdCl2,,(PPh3)(2) and Et3N in DMF at 90 degreesC affords 2-(o-trifluoroacetamidoaryl)indoles. The presence of the free amino group was found to play a crucial role in favoring the cyclization step.File in questo prodotto:
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