Summary Background The eff ect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is off set by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia. Methods We undertook a parallel group, multicentre, randomised controlled trial of 3526 patients with symptomatic or asymptomatic carotid stenosis from 95 centres in 24 countries. Participants were randomly assigned to surgery under general (n=1753) or local (n=1773) anaesthesia between June, 1999 and October, 2007. The primary outcome was the proportion of patients with stroke (including retinal infarction), myocardial infarction, or death between randomisation and 30 days after surgery. Analysis was by intention to treat. The trial is registered with Current Control Trials number ISRCTN00525237. Findings A primary outcome occurred in 84 (4•8%) patients assigned to surgery under general anaesthesia and 80 (4•5%) of those assigned to surgery under local anaesthesia; three events per 1000 treated were prevented with local anaesthesia (95% CI –11 to 17; risk ratio [RR] 0•94 [95% CI 0•70 to 1•27]). The two groups did not signifi cantly diff er for quality of life, length of hospital stay, or the primary outcome in the prespecifi ed subgroups of age, contralateral carotid occlusion, and baseline surgical risk. Interpretation We have not shown a defi nite diff erence in outcomes between general and local anaesthesia for carotid surgery. The anaesthetist and surgeon, in consultation with the patient, should decide which anaesthetic technique to use on an individual basis.

General anaesthesia versus local anaesthesia for carotid surgery (GALA): a multicentre, randomised controlled trial

CICCOZZI, ALESSANDRA;PETRASSI, CARLA;PIROLI, ALBA;VENTURA, Marco
2008

Abstract

Summary Background The eff ect of carotid endarterectomy in lowering the risk of stroke ipsilateral to severe atherosclerotic carotid-artery stenosis is off set by complications during or soon after surgery. We compared surgery under general anaesthesia with that under local anaesthesia because prediction and avoidance of perioperative strokes might be easier under local anaesthesia than under general anaesthesia. Methods We undertook a parallel group, multicentre, randomised controlled trial of 3526 patients with symptomatic or asymptomatic carotid stenosis from 95 centres in 24 countries. Participants were randomly assigned to surgery under general (n=1753) or local (n=1773) anaesthesia between June, 1999 and October, 2007. The primary outcome was the proportion of patients with stroke (including retinal infarction), myocardial infarction, or death between randomisation and 30 days after surgery. Analysis was by intention to treat. The trial is registered with Current Control Trials number ISRCTN00525237. Findings A primary outcome occurred in 84 (4•8%) patients assigned to surgery under general anaesthesia and 80 (4•5%) of those assigned to surgery under local anaesthesia; three events per 1000 treated were prevented with local anaesthesia (95% CI –11 to 17; risk ratio [RR] 0•94 [95% CI 0•70 to 1•27]). The two groups did not signifi cantly diff er for quality of life, length of hospital stay, or the primary outcome in the prespecifi ed subgroups of age, contralateral carotid occlusion, and baseline surgical risk. Interpretation We have not shown a defi nite diff erence in outcomes between general and local anaesthesia for carotid surgery. The anaesthetist and surgeon, in consultation with the patient, should decide which anaesthetic technique to use on an individual basis.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/7730
Citazioni
  • ???jsp.display-item.citation.pmc??? 62
  • Scopus 450
  • ???jsp.display-item.citation.isi??? 360
social impact