Osteoporosis is a major cause of morbidity in older people. There are a large number of risk factors for the development of senile osteoporosis. Howeover, recent discoveries suggest that these risk factors could exert their effects through immunologically mediated modulation of bone remodelling. Infl amm-ageing itself plays a role in bone remodelling through pro-infl ammatory cytokines, which are known to infl uence osteoclasts and osteoblasts, together with other more recently discovered immunological mediators and transcription factors. Senile osteoporosis is an example of the central role of immune-mediated infl ammation in determining bone resorption. In this review, we will discuss the pathogenesis of osteoporosis in the context of immunosenescence.
Senile osteoporosis: is it an immune-mediated disease?
DE MARTINIS, MASSIMO MARIA MARCELLO;GINALDI, Lia
2006-01-01
Abstract
Osteoporosis is a major cause of morbidity in older people. There are a large number of risk factors for the development of senile osteoporosis. Howeover, recent discoveries suggest that these risk factors could exert their effects through immunologically mediated modulation of bone remodelling. Infl amm-ageing itself plays a role in bone remodelling through pro-infl ammatory cytokines, which are known to infl uence osteoclasts and osteoblasts, together with other more recently discovered immunological mediators and transcription factors. Senile osteoporosis is an example of the central role of immune-mediated infl ammation in determining bone resorption. In this review, we will discuss the pathogenesis of osteoporosis in the context of immunosenescence.Pubblicazioni consigliate
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