A new NMR method is presented to measure selectively the self-diffusion coefficient of molecules with 13C–1H bonds. The method is based on the selection of spectral lines by both 13C chemical-shift and 13C–1H J-coupling encoding, which generally is adequate to individuate a molecular species. Although the approach has preferential utilization in bio-molecular systems, it may be employed when a direct or indirect chemical bond has chemical shift and J-coupling coordinates able to localize uniquely a certain molecular species. The method may also be utilized to attain self-diffusion weighted NMR imaging (MRI) of single molecular species. Here results on glucose metabolites in aqueous solutions are presented. The approach shows a chemical selectivity, which is higher than the traditional NMR stimulated echo approach.
Molecular Self-Diffusion Measurement by Stimulated Echo of Selected 13C-1H Bonds: Case of Glucose Metabolites
CASIERI RUSSO, Cinzia;
2004-01-01
Abstract
A new NMR method is presented to measure selectively the self-diffusion coefficient of molecules with 13C–1H bonds. The method is based on the selection of spectral lines by both 13C chemical-shift and 13C–1H J-coupling encoding, which generally is adequate to individuate a molecular species. Although the approach has preferential utilization in bio-molecular systems, it may be employed when a direct or indirect chemical bond has chemical shift and J-coupling coordinates able to localize uniquely a certain molecular species. The method may also be utilized to attain self-diffusion weighted NMR imaging (MRI) of single molecular species. Here results on glucose metabolites in aqueous solutions are presented. The approach shows a chemical selectivity, which is higher than the traditional NMR stimulated echo approach.Pubblicazioni consigliate
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