The palladium-catalysed reaction of 5(trimethylsilylethynyl)-3',5'-di-O-acetyl-2'-deoxyuridine with aryl iodides in the presence of n-Bu(4)NF and triethylamine under a balloon of carbon monoxide produces 5-(2-acylethynyl)-3',5'-di-O-acetyl-2'-deoxyuridines in good yields at room temperature. The methodology has been extended to the preparation of alpha,beta-ynones from 1-alkynes and aryl iodides.
THE PALLADIUM-CATALYZED CARBONYLATIVE COUPLING OF 5-(TRIMETHYLSILYLETHYNYL)-3',5'-DI-O-ACETYL-2' DEOXYURIDINE AND 1-ALKYNES WITH ARYL IODIDES
ARCADI A;MARINELLI, Fabio;
1995-01-01
Abstract
The palladium-catalysed reaction of 5(trimethylsilylethynyl)-3',5'-di-O-acetyl-2'-deoxyuridine with aryl iodides in the presence of n-Bu(4)NF and triethylamine under a balloon of carbon monoxide produces 5-(2-acylethynyl)-3',5'-di-O-acetyl-2'-deoxyuridines in good yields at room temperature. The methodology has been extended to the preparation of alpha,beta-ynones from 1-alkynes and aryl iodides.File in questo prodotto:
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