The in vitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mgmL1 for sphaerophorin to 1024 mgmL1 for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy. © 2013 Taylor & Francis.
Antibacterial activity of selected metabolites from Chilean lichen species against methicillin-resistant staphylococci
CELENZA, GIUSEPPE;PERILLI, MARIAGRAZIA;BRISDELLI, FABRIZIA;Bellio P;AMICOSANTE, Gianfranco;
2013-01-01
Abstract
The in vitro antibacterial activities of eight compounds isolated from lichens, collected in several Southern regions of Chile (including Antarctica), were evaluated against methicillin-resistant clinical isolates strains of Staphylococcus aureus, Staphylococcus haemolyticus and Staphylococcus warneri. The minimum inhibitory concentrations, calculated in microdilution, were ranging from 8 mgmL1 for sphaerophorin to 1024 mgmL1 for fumarprotocetraric acid. These findings suggest, however, that the natural compounds from lichens are good candidates for the individuation of novel templates for the development of new antimicrobial agents or combinations of drugs for chemotherapy. © 2013 Taylor & Francis.Pubblicazioni consigliate
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