"Free NH 2-substituted 3-arylindoles have been prepared usually in good to high yields through the palladium-catalyzed reaction of. readily available 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions. The reaction tolerates a variety of useful functional groups both in the arylboronic acid and in the alkyne, including chloro, formyl, and ester groups."
2-Substituted 3-Arylindoles Through Palladium-Catalyzed Arylative Cyclization of 2-Alkynyltrifluoroacetanilides with Arylboronic Acids under Oxidative Conditions
ARCADI, Antonio;MARINELLI, Fabio
2013-01-01
Abstract
"Free NH 2-substituted 3-arylindoles have been prepared usually in good to high yields through the palladium-catalyzed reaction of. readily available 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions. The reaction tolerates a variety of useful functional groups both in the arylboronic acid and in the alkyne, including chloro, formyl, and ester groups."File in questo prodotto:
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