"BACKGROUND: Few data exist on the relationship between psoriasis and melanocytic lesions.. . OBJECTIVES: We sought to investigate number of melanocytic nevi in psoriatic patients compared with control subjects and its relationship with disease severity and treatment.. . METHODS: We performed a prospective study in 189 psoriatic patients and 189 control subjects. Sociodemographic and clinical data were recorded for all participants.. . RESULTS: As compared with control subjects, patients had fewer nevi overall [χ(2)(5) = 52.24, P < .001], fewer nevi less than 5 mm [χ(2)(4) = 60.28, P < .001], and fewer congenital nevi [χ(2)(1) = 10.41, P = .002]; no differences in atypical nevi and family history of cancer, including melanoma, were observed. Among psoriatic patients, number of biologics used was a risk factor for a higher nevus count [odds ratio 1.35 (95% CI 1.04-1.76), P = .02] whereas disease severity did not correlate with number of nevi.. . LIMITATIONS: Low number of psoriatic patients naïve to systemic therapies was a limitation.. . CONCLUSIONS: Psoriatic patients have fewer nevi than control subjects. Frequency of nevi in psoriatic patients is related to treatment, not to disease severity.. "

Frequency of melanocytic nevi in psoriatic patients is related to treatment and not to disease severity

Esposito M;FARGNOLI, MARIA CONCETTA;PERIS, KETTY
2013-01-01

Abstract

"BACKGROUND: Few data exist on the relationship between psoriasis and melanocytic lesions.. . OBJECTIVES: We sought to investigate number of melanocytic nevi in psoriatic patients compared with control subjects and its relationship with disease severity and treatment.. . METHODS: We performed a prospective study in 189 psoriatic patients and 189 control subjects. Sociodemographic and clinical data were recorded for all participants.. . RESULTS: As compared with control subjects, patients had fewer nevi overall [χ(2)(5) = 52.24, P < .001], fewer nevi less than 5 mm [χ(2)(4) = 60.28, P < .001], and fewer congenital nevi [χ(2)(1) = 10.41, P = .002]; no differences in atypical nevi and family history of cancer, including melanoma, were observed. Among psoriatic patients, number of biologics used was a risk factor for a higher nevus count [odds ratio 1.35 (95% CI 1.04-1.76), P = .02] whereas disease severity did not correlate with number of nevi.. . LIMITATIONS: Low number of psoriatic patients naïve to systemic therapies was a limitation.. . CONCLUSIONS: Psoriatic patients have fewer nevi than control subjects. Frequency of nevi in psoriatic patients is related to treatment, not to disease severity.. "
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/88965
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