""Bone is a peculiar connective tissue which. functionally interacts with many other organs and tissues,. including bone marrow, lymphoid tissue, kidney, adipose. tissue, endocrine pancreas, brain and gonads. Bone functions. are accomplished by three principal cell types: the osteoblasts,. cells of mesenchymal origin having osteogenic functions, the. osteoclasts, giant multinucleated cells arising from the. monocyte-macrophage line and devoted to resorb bone, and. the osteocytes, the latter arising from mature osteoblasts that,. once deposited the bone matrix, remain trapped in it, becoming. quiescent cells. Osteocytes are known for their role as. mechanosensors, however, old and new evidence showed their. active contribution to mineral homeostasis. Moreover, the. cross-talk between bone cells is crucial, since a correct bone. homeostasis relies on a right coupling between osteoblast and. osteoclast functions. Any deregulation of this coupling is. responsible for bone disease condition, which reflects on other. organs with which bone interacts.""

Bone cells and the mechanisms of bone remodeliling

TETI, ANNA MARIA;RUCCI, Nadia
2012-01-01

Abstract

""Bone is a peculiar connective tissue which. functionally interacts with many other organs and tissues,. including bone marrow, lymphoid tissue, kidney, adipose. tissue, endocrine pancreas, brain and gonads. Bone functions. are accomplished by three principal cell types: the osteoblasts,. cells of mesenchymal origin having osteogenic functions, the. osteoclasts, giant multinucleated cells arising from the. monocyte-macrophage line and devoted to resorb bone, and. the osteocytes, the latter arising from mature osteoblasts that,. once deposited the bone matrix, remain trapped in it, becoming. quiescent cells. Osteocytes are known for their role as. mechanosensors, however, old and new evidence showed their. active contribution to mineral homeostasis. Moreover, the. cross-talk between bone cells is crucial, since a correct bone. homeostasis relies on a right coupling between osteoblast and. osteoclast functions. Any deregulation of this coupling is. responsible for bone disease condition, which reflects on other. organs with which bone interacts.""
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/89465
Citazioni
  • ???jsp.display-item.citation.pmc??? 33
  • Scopus 74
  • ???jsp.display-item.citation.isi??? ND
social impact