"\"Deterioration of semantic memory is one of the primary neuropsychological deficits. caused by Alzheimer’s disease (AD). In this study, we hypothesize that the breakdown. of semantic memory in the mild-to-moderate stage of AD is due to the disruption of the. semantic network that links the concepts. Furthermore, the loss of these links is not. homogeneous through the semantic association categories (i.e., Superordinate,. Contiguity, Part=Whole, Attribute, Function). Twenty-two subjects (11 patients with. mild-to-moderate dementia and 11 control subjects matched on demographics) participated. in the study. Both controls and patients with AD underwent extensive neuropsychological. evaluation and three experimental tasks: (1) Naming Task, (2) Semantic. Association Task, and (3) Semantic Knowledge Task. Results showed that: (1) The. AD group was significantly different from the normal controls group in all the. experimental tasks; (2) the Semantic Association Task was significantly worse than. the other tasks; (3) for the AD group, the scores of the Function and Part=Whole association. categories were higher than in the other categories; and (4) living stimuli were. more impaired than nonliving. These data confirm prior research showing the semantic. association is differently impaired in AD patients.\""

Loss of semantic associative categories in patients with Alzheimer's disease

PASSAFIUME, Domenico;DI GIACOMO, DINA
2012-01-01

Abstract

"\"Deterioration of semantic memory is one of the primary neuropsychological deficits. caused by Alzheimer’s disease (AD). In this study, we hypothesize that the breakdown. of semantic memory in the mild-to-moderate stage of AD is due to the disruption of the. semantic network that links the concepts. Furthermore, the loss of these links is not. homogeneous through the semantic association categories (i.e., Superordinate,. Contiguity, Part=Whole, Attribute, Function). Twenty-two subjects (11 patients with. mild-to-moderate dementia and 11 control subjects matched on demographics) participated. in the study. Both controls and patients with AD underwent extensive neuropsychological. evaluation and three experimental tasks: (1) Naming Task, (2) Semantic. Association Task, and (3) Semantic Knowledge Task. Results showed that: (1) The. AD group was significantly different from the normal controls group in all the. experimental tasks; (2) the Semantic Association Task was significantly worse than. the other tasks; (3) for the AD group, the scores of the Function and Part=Whole association. categories were higher than in the other categories; and (4) living stimuli were. more impaired than nonliving. These data confirm prior research showing the semantic. association is differently impaired in AD patients.\""
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/89767
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