The ancient genomic DNA (anDNA) and analysis of genetic risk factors related to autoimmune rheumatic diseases HLA linked A. Poma, S. Colafarina, G. Fontecchio; University of L‘Aquila, L‘Aquila, Italy. The mountain areas of L’Aquila city, such as Barete and Rocca di Cambio are characterized by environmental conditions (low temperature and humidity) that facilitate the preservation of the humans remains and anDNA: this factor explains the often tempering of a number of paleoanthropological findings. The migratory events surely resulted in the disappearance of several genes as well as the introduction of foreign alleles, among which some responsible for the development of autoimmune diseases HLA-restricted. In this work we show some preliminary genetic data generated by applying different bone anDNA extraction protocols, innovative and/or suitably modified from commercially available kits for forensic analysis. The immunogenetic assays have showed the positivity for HLA gene HLA-Cw3 (an increased frequency of HLA-Cw3 and HLA-Dw4 is tipically observed in Rheumatoid Arthritis). This work has laid the foundation for the design of protocols for extraction and PCR reaction improved and optimized, to be applied to paleogenetics and paleopathology samples on which to assess genetic risk factors related to autoimmune rheumatic diseases „HLA-Linked“.References Fontecchio G., Ventura L., Poma A.M., 2012; Further genomic testing and histological examinations confirm the diagnosis of rheumatoid arthritis in an Italian mummy from the 16th century, 2012; Ann. Rheum. Dis., 71: 630. Poma A., Carlucci G, Fontecchio G., 2012; Immunogenetics and HPLC analyses contribute to understanding the etiopathology of rheumatoid arthritis through studies on ancient human remains, Int. J. Immunopathol. Pharmacol., 25: 1075-1082. This work was partially funded (2013) to A. Poma by ANCE Associazione Nazionale Costruttori Edili L’Aquila

The ancient genomic DNA (anDNA) and analysis of genetic risk factors related to autoimmune rheumatic diseases HLA linked

Poma A
2014-01-01

Abstract

The ancient genomic DNA (anDNA) and analysis of genetic risk factors related to autoimmune rheumatic diseases HLA linked A. Poma, S. Colafarina, G. Fontecchio; University of L‘Aquila, L‘Aquila, Italy. The mountain areas of L’Aquila city, such as Barete and Rocca di Cambio are characterized by environmental conditions (low temperature and humidity) that facilitate the preservation of the humans remains and anDNA: this factor explains the often tempering of a number of paleoanthropological findings. The migratory events surely resulted in the disappearance of several genes as well as the introduction of foreign alleles, among which some responsible for the development of autoimmune diseases HLA-restricted. In this work we show some preliminary genetic data generated by applying different bone anDNA extraction protocols, innovative and/or suitably modified from commercially available kits for forensic analysis. The immunogenetic assays have showed the positivity for HLA gene HLA-Cw3 (an increased frequency of HLA-Cw3 and HLA-Dw4 is tipically observed in Rheumatoid Arthritis). This work has laid the foundation for the design of protocols for extraction and PCR reaction improved and optimized, to be applied to paleogenetics and paleopathology samples on which to assess genetic risk factors related to autoimmune rheumatic diseases „HLA-Linked“.References Fontecchio G., Ventura L., Poma A.M., 2012; Further genomic testing and histological examinations confirm the diagnosis of rheumatoid arthritis in an Italian mummy from the 16th century, 2012; Ann. Rheum. Dis., 71: 630. Poma A., Carlucci G, Fontecchio G., 2012; Immunogenetics and HPLC analyses contribute to understanding the etiopathology of rheumatoid arthritis through studies on ancient human remains, Int. J. Immunopathol. Pharmacol., 25: 1075-1082. This work was partially funded (2013) to A. Poma by ANCE Associazione Nazionale Costruttori Edili L’Aquila
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/130425
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