We used functional magnetic resonance imaging (fMRI) in conjunction with a voxel-based approach to lesion symptom mapping to quantitatively evaluate the similarities and differences between brain areas involved in language and environmental sound comprehension. In general, we found that language and environmental sounds recruit highly overlapping cortical regions, with cross-domain differences being graded rather than absolute. Within language-based regions of interest, we found that in the left hemisphere, language and environmental sound stimuli evoked very similar volumes of activation, whereas in the right hemisphere, there was greater activation for environmental sound stimuli. Finally, lesion symptom maps of aphasic patients based on environmental sounds or linguistic deficits were generally predictive of the extent of blood oxygenation level dependent fMRI activation across these regions for sounds and linguistic stimuli in young healthy subjects.

What is involved and what is necessary for complex linguistic and non- linguistic auditory processing: Evidence from fMRI and lesion data

D'AMICO, SIMONETTA;
2007

Abstract

We used functional magnetic resonance imaging (fMRI) in conjunction with a voxel-based approach to lesion symptom mapping to quantitatively evaluate the similarities and differences between brain areas involved in language and environmental sound comprehension. In general, we found that language and environmental sounds recruit highly overlapping cortical regions, with cross-domain differences being graded rather than absolute. Within language-based regions of interest, we found that in the left hemisphere, language and environmental sound stimuli evoked very similar volumes of activation, whereas in the right hemisphere, there was greater activation for environmental sound stimuli. Finally, lesion symptom maps of aphasic patients based on environmental sounds or linguistic deficits were generally predictive of the extent of blood oxygenation level dependent fMRI activation across these regions for sounds and linguistic stimuli in young healthy subjects.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/1736
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 48
social impact