Lives on earth are regulated by of complex system of interactions. Modelling those interactions through the network paradigms allows researchers to discover and understand the fundamental molecular mechanisms which drive the biological processes and lead to humans diseases. The advancement made in the development of sequencing technologies has produced a growing amount of biological data. The aforementioned preconditions are at the base of a flourishing production of Deep Learning methods able to cope with the complexity and the data abundance of this domain. For those reasons, this chapter provides a comprehensive overview of the recent advancement in the deep learning network-based approaches focusing on biology, medicine and pharmacological crucial research's problems. At first, the needed biological and network science backgrounds are presented. Secondly, a comprehensive overview of the biologicals' networks and resources are provided. Finally, we will discuss the most recent methods in the field organising them into three broad categories related to the Interactome, the Network Pharmacology, and the frontier biologicals problems.

Deep Learning Methods for Network Biology

G. Stilo
Membro del Collaboration Group
2022

Abstract

Lives on earth are regulated by of complex system of interactions. Modelling those interactions through the network paradigms allows researchers to discover and understand the fundamental molecular mechanisms which drive the biological processes and lead to humans diseases. The advancement made in the development of sequencing technologies has produced a growing amount of biological data. The aforementioned preconditions are at the base of a flourishing production of Deep Learning methods able to cope with the complexity and the data abundance of this domain. For those reasons, this chapter provides a comprehensive overview of the recent advancement in the deep learning network-based approaches focusing on biology, medicine and pharmacological crucial research's problems. At first, the needed biological and network science backgrounds are presented. Secondly, a comprehensive overview of the biologicals' networks and resources are provided. Finally, we will discuss the most recent methods in the field organising them into three broad categories related to the Interactome, the Network Pharmacology, and the frontier biologicals problems.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/178193
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