Synergistic Organo‐Organocatalysis

Asymmetric organocatalysis is pivotal in the field of asymmetric catalysis and is a crucial technology platform in the industry. However, in some cases, catalysis may have reached its limit and synergistic catalysis is an interesting groundbreaking strategy to go beyond the established limits and perform unprecedented reactions. This type of catalysis does not come without its own challenges; in fact, an appropriate combination of catalysts is required to avoid self-quenching of the catalysts. This chapter will focus on synergistic catalysis mediated by two distinct organocatalysts that act separately to activate the reaction partners. Selected reactions for different types of activations will be discussed, highlighting the development that brought to their discovery.