Purpose: To assess the efficacy of ultrasmall superparamegnetic iron oxide (Sinerem, Guerbet, France) in the differentiation of metastatic and benign lymph nodes. Material and methods: MR studies were performed with 1.5 T superconducting imaging sistem (GE Signa Horizon 8.3 Echo Speed, Milwaukee, USA). Seven adults suspected of having lymph node metastases underwent MR examination 24 - 28 hours after intravenous infusion of Sinerem. Two radiologists interpreted the post-contrast modification of signal intensity of the lymph nodes on the T2* weighted gradient-echo images. MR findings were compared with histopathologic findings at the corresponding site. Result: Twelve lymph nodes were available for histopathologic examination. Histopathologic examination showed 7 normal nodes and 5 metastatic nodes. All metastatic nodes showed an increase in signal intensity on postcontrast GRE T2*-weighted MR images. Five normal nodes showed decrease in signal intensity, indicating active USPIOs uptake by macrophages. Two normal lymph nodes, with increase in signal intensity, were interpreted as positive. In this case, the examination presented more artefacts. MR showed sensitivity of 71 %, specificity of 100 % and accuracy of 82 %. Conclusion: This study suggests that USPIOs might be used to facilitate the differentiation between metastatic and benign nodes. Additional studies are needed to confirm these data.

SE 106 - Contrast Media MR imaging of lymph nodes in patient with cancer using ultrasmall superparamegnetic iron oxide (USPIOs): Initial clinical experience

DI CESARE, Ernesto;MASCIOCCHI, CARLO
2002

Abstract

Purpose: To assess the efficacy of ultrasmall superparamegnetic iron oxide (Sinerem, Guerbet, France) in the differentiation of metastatic and benign lymph nodes. Material and methods: MR studies were performed with 1.5 T superconducting imaging sistem (GE Signa Horizon 8.3 Echo Speed, Milwaukee, USA). Seven adults suspected of having lymph node metastases underwent MR examination 24 - 28 hours after intravenous infusion of Sinerem. Two radiologists interpreted the post-contrast modification of signal intensity of the lymph nodes on the T2* weighted gradient-echo images. MR findings were compared with histopathologic findings at the corresponding site. Result: Twelve lymph nodes were available for histopathologic examination. Histopathologic examination showed 7 normal nodes and 5 metastatic nodes. All metastatic nodes showed an increase in signal intensity on postcontrast GRE T2*-weighted MR images. Five normal nodes showed decrease in signal intensity, indicating active USPIOs uptake by macrophages. Two normal lymph nodes, with increase in signal intensity, were interpreted as positive. In this case, the examination presented more artefacts. MR showed sensitivity of 71 %, specificity of 100 % and accuracy of 82 %. Conclusion: This study suggests that USPIOs might be used to facilitate the differentiation between metastatic and benign nodes. Additional studies are needed to confirm these data.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11697/24827
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