Systemic delivery of drugs by percutaneous permeation (transdermal drug delivery, TDD) offers several advantages compared to oral release or hypodermic injection. Because TDD’s controlled release rate can provide a constant concentration for a long period of time and improved patient compliance, TDD has been shown to be an attractive alternative to oral administration [1]. The most advanced delivery systems (electroporation and cavitational ultrasound) enhance transdermal delivery through a strong and reversible disruption of the stratum corneum (SC), without damaging the deeper tissues.
Transdermal Drug Delivery and Percutaneous Absorption: Mathematical Modeling Perspectives, Chapter 10
DE MONTE, FILIPPO;
2015-01-01
Abstract
Systemic delivery of drugs by percutaneous permeation (transdermal drug delivery, TDD) offers several advantages compared to oral release or hypodermic injection. Because TDD’s controlled release rate can provide a constant concentration for a long period of time and improved patient compliance, TDD has been shown to be an attractive alternative to oral administration [1]. The most advanced delivery systems (electroporation and cavitational ultrasound) enhance transdermal delivery through a strong and reversible disruption of the stratum corneum (SC), without damaging the deeper tissues.File in questo prodotto:
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