Giant Schawannoma of Oral Floor

Abstract: Schwannoma (Neurilemmoma) is a benign, slow-growing tumor that originates from the presence of Schwann cells of the peripheral nerves. They is usually asymptomatic, do not recur, and malignant transformation is rare. The Schwannoma is usually found in the head and neck (i.e. acoustic neuromas) or in autosomic dominant disorder with moutation of the NF2 gene on chromosome 22 (22q12). It’s rarely in the oral cavity. It can present itself at any age. This lesion is not taken into account during clinical practice and the differential diagnosis includes numerous benign neoformations based on epithelial and connective tissues. In the majority of cases, the diagnosis can only be made during surgery and by histological study, however the preoperative tomography and magnetic resonance imaging are helpful. The Schwannoma showed two different pattern of growth: Antoni A and Antoni B. The Anti-S-100, NSE protein is the most used antibody to identify the neoplasm. The authors describe a case of slow growing mass, in the oral mouth floor, the surgical choice treatment and the outcome at follow-up.