"Background: Ovotransferrin is an iron-binding glycoprotein, found in avian egg white and in avian serum,. belonging to the family of transferrin iron-binding glycoproteins. All transferrins show high sequence. homology. In mammals are presents two different soluble glycoproteins with different functions: i) serum. transferrin that is present in plasma and committed to iron transport and iron delivery to cells and. ii) lactoferrin that is present in extracellular fluids and in specific granules of polymorphonuclear. lymphocytes and committed to the so-called natural immunity. To the contrary, in birds, ovotransferrin. remained the only soluble glycoprotein of the transferrin family present both in plasma and egg white.. Scope of review: Substantial experimental evidences are summarized, illustrating the multiple physiological. roles of ovotransferrin in an attempt to overcome the common belief that ovotransferrin is a protein dedicated. only to iron transport and to iron withholding antibacterial activity.. Major conclusions: Similarly to the better known familymember protein lactoferrin, ovotransferrin appears to. be a multi-functional protein with a major role in avian natural immunity.. General significance: Biotechnological applications of ovotransferrin and ovotransferrin-related peptides could. be considered in the near future, stimulating further research on this remarkable protein."

Physiological roles of ovotransferrin

GIANSANTI, FRANCESCO;PITARI, Giuseppina;IPPOLITI, RODOLFO;
2012-01-01

Abstract

"Background: Ovotransferrin is an iron-binding glycoprotein, found in avian egg white and in avian serum,. belonging to the family of transferrin iron-binding glycoproteins. All transferrins show high sequence. homology. In mammals are presents two different soluble glycoproteins with different functions: i) serum. transferrin that is present in plasma and committed to iron transport and iron delivery to cells and. ii) lactoferrin that is present in extracellular fluids and in specific granules of polymorphonuclear. lymphocytes and committed to the so-called natural immunity. To the contrary, in birds, ovotransferrin. remained the only soluble glycoprotein of the transferrin family present both in plasma and egg white.. Scope of review: Substantial experimental evidences are summarized, illustrating the multiple physiological. roles of ovotransferrin in an attempt to overcome the common belief that ovotransferrin is a protein dedicated. only to iron transport and to iron withholding antibacterial activity.. Major conclusions: Similarly to the better known familymember protein lactoferrin, ovotransferrin appears to. be a multi-functional protein with a major role in avian natural immunity.. General significance: Biotechnological applications of ovotransferrin and ovotransferrin-related peptides could. be considered in the near future, stimulating further research on this remarkable protein."
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11697/89799
Citazioni
  • ???jsp.display-item.citation.pmc??? 30
  • Scopus 94
  • ???jsp.display-item.citation.isi??? 93
social impact